4.7 Review

Point-of-care biochemical assays using electrochemical technologies: approaches, applications, and opportunities

Journal

MICROCHIMICA ACTA
Volume 189, Issue 8, Pages -

Publisher

SPRINGER WIEN
DOI: 10.1007/s00604-022-05425-z

Keywords

Electrochemical biosensors; In vitro diagnosis (IVD); Point-of-care; Biological compounds; Tumor markers

Funding

  1. National Key Research and Development Program of China [2017FYA0205303]
  2. National Natural Science Foundation of China [32171373]
  3. Medical Engineering Cross Project of SJTU [YG2019QNB09, YG2021QN141]

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This article explores the potential of electrochemical biosensors in real-time healthcare monitoring. It discusses the classification and comparison of commonly available electrochemical biosensors, and focuses on recent studies and applications. The article also identifies research gaps and proposes strategies for improvement, providing new guidelines for the advanced research and wider applications of electrochemical biosensors in in vitro diagnosis.
Against the backdrop of hidden symptoms of diseases and limited medical resources of their investigation, in vitro diagnosis has become a popular mode of real-time healthcare monitoring. Electrochemical biosensors have considerable potential for use in wearable products since they can consistently monitor the physiological information of the patient. This review classifies and briefly compares commonly available electrochemical biosensors and the techniques of detection used. Following this, the authors focus on recent studies and applications of various types of sensors based on a variety of methods to detect common compounds and cancer biomarkers in humans. The primary gaps in research are discussed and strategies for improvement are proposed along the dimensions of hardware and software. The work here provides new guidelines for advanced research on and a wider scope of applications of electrochemical biosensors to in vitro diagnosis.

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