Autoimmune hepatitis: Challenges and novelties

Autoimmune hepatitis is a chronic inflammatory disease of the liver. The etiology is partly unknown and commonly affects women of all ages. It is characterized by increase in transaminase and immuno-globulin G levels, autoantibodies, and portal inflammatory infiltrate with interface hepatitis in the liver biopsy. The treatment is based on the combination of corticoids and azathioprine, but 20-40% of patients require second-or third-line therapies due to intolerance or insufficient response. Here, we will revise the most important aspects regarding the diagnosis and treatment of autoimmune hepatitis emphasizing the challenges faced in clinical practice.(c) 2022 Elsevier Espana, S.L.U. All rights reserved.

Automated summary

Autoimmune hepatitis is a chronic liver disease characterized by liver inflammation, elevated transaminase and immunoglobulin G levels, autoantibodies, and inflammatory infiltrate in liver biopsy. The treatment involves the combination of corticoids and azathioprine, but some patients require second- or third-line therapies.