Journal
MEDICAL AND VETERINARY ENTOMOLOGY
Volume 37, Issue 2, Pages 209-212Publisher
WILEY
DOI: 10.1111/mve.12596
Keywords
insecticide resistance; kdr mutation; pediculosis; pyrethroid; voltage-gated sodium channel
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This study aims to determine the presence of kdr mutations in the population of Indian head lice. By sequencing the genome of head louse samples collected from different regions of India, four kdr mutations were detected. Among them, L1014F is the most commonly reported mutation associated with the kdr trait in insect taxa.
There are at least three known knockdown resistance (kdr) mutations reported globally in the human head louse Pediculus humanus capitis De Geer (Phthiraptera: Anoplura) that are associated with reduced sensitivity to pyrethroids. However, the prevalence of kdr mutation in head lice is not known in the Indian subcontinent. To identify kdr mutations in the Indian head lice population, the genomic region of the voltage-gated sodium channel gene encompassing IIS1-2 linker to IIS6 segments was PCR-amplified and sequenced from P. humanus capitis samples collected from different geographic localities of India. DNA sequencing revealed the presence of four kdr mutations: M827I, T929I, L932F and L1014F. The presence of a classical kdr mutation L1014F, the most widely reported mutation across insect-taxa associated with the kdr-trait, is being reported for the first time in P. humanus capitis.
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