4.5 Review

Insights into the Anti-inflammatory and Antiviral Mechanisms of Resveratrol

Journal

MEDIATORS OF INFLAMMATION
Volume 2022, Issue -, Pages -

Publisher

HINDAWI LTD
DOI: 10.1155/2022/7138756

Keywords

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Funding

  1. Program Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System
  2. Science and Technology Project of Sichuan Province
  3. [SCCXTD-2020-18]
  4. [2021NZZJ0021]

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Resveratrol, a naturally occurring compound in plants, has been extensively studied for its anti-inflammatory and antiviral activities. It is believed that the NF-kappa B signaling pathway plays a key role in the mechanisms of resveratrol. Future studies should focus on upstream signaling molecules of the NF-kappa B pathway and the interaction between resveratrol and key proteins/enzymes of viruses. The clinical application of resveratrol is also of great importance.
Resveratrol is a naturally occurring stilbene phytoalexin phenolic compound, which has been extensively studied on its biological activity. It has been widely accepted that resveratrol possesses anti-inflammatory and antiviral activities. In this review, we summarize the anti-inflammatory dosages and mechanism and antiviral mechanism of resveratrol. Since viral infections are often accompanied by inflammation, we propose that the NF-kappa B signaling pathway is a key and common molecular mechanism of resveratrol to exert anti-inflammatory and antiviral effects. For future studies, we believe that resveratrol's anti-inflammatory and antiviral mechanisms can consider the upstream signaling molecules of the NF-kappa B signaling pathway. For resveratrol antivirus, future studies can be conducted on the interaction of resveratrol with key proteins or important enzymes of the virus. In addition, we also think that the clinical application of resveratrol is very important. In short, resveratrol is a promising anti-inflammatory and antiviral drug, and research on it needs to be expanded.

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