4.5 Article

CD226 Deficiency Alleviates Murine Allergic Rhinitis by Suppressing Group 2 Innate Lymphoid Cell Responses

Related references

Note: Only part of the references are listed.
Editorial Material Allergy

Immune checkpoint molecules on ILC2s as potential therapeutic targets for allergic diseases

Hideaki Morita et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Allergy

A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation

Liuhui Fu et al.

Summary: This study reveals that the mitochondrial STAT3-methionine metabolism pathway is a key regulator of ILC2 effector function through epigenetic regulation. By promoting epigenetic reprogramming, this pathway further enhances ILC2-driven allergic lung inflammation. These findings suggest that the related proteins or metabolites could represent potential therapeutic targets for allergic lung inflammation.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Immunology

Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity

Jingjing Zhang et al.

Summary: This study identifies neuropilin-1 (Nrp1) as a tissue-specific marker of lung-resident ILC2s, which enhances their function and type 2 immune response by upregulating IL-33 receptor ST2 expression. Inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis.

NATURE IMMUNOLOGY (2022)

Article Biochemical Research Methods

Comprehensive Phenotyping of Peripheral Blood T Lymphocytes in Healthy Mice

Genny Del Zotto et al.

Summary: T lymphocytes play a central role in antigen-specific immune responses by regulating immune cell function and directly killing target cells. They originate from bone marrow, differentiate in the thymus, and migrate to secondary lymphoid organs, with subsets identified based on markers and cytokine production profiles. This review provides an overview of T-cell subpopulations and differentiation states from a cytometric perspective.

CYTOMETRY PART A (2021)

Article Integrative & Complementary Medicine

Acupuncture inhibited airway inflammation and group 2 innate lymphoid cells in the lung in an ovalbumin-induced murine asthma model

Jie Cui et al.

Summary: The study demonstrates that acupuncture treatment can significantly suppress allergic airway inflammation and mucus secretion, decrease airway resistance while increasing lung dynamic compliance, and reduce the levels of inflammatory cytokines in the airways. Acupuncture also inhibits the influx of pulmonary ILC2s and production of IL-5, IL-9, and IL-13, providing protection against respiratory inflammation associated with asthma.

ACUPUNCTURE IN MEDICINE (2021)

Review Chemistry, Medicinal

TIGIT/CD226 Axis Regulates Anti-Tumor Immunity

Jinah Yeo et al.

Summary: Although immune checkpoint blockade therapies have shown efficacy in multiple cancer indications, only a subset of patients benefit from them, highlighting the need for new approaches. TIGIT and CD226, as regulators of immune cells, have potential applications in cancer immunotherapy as they act on different pathways to modulate immune responses.

PHARMACEUTICALS (2021)

Review Oncology

Poliovirus receptor (PVR)-like protein cosignaling network: new opportunities for cancer immunotherapy

Baokang Wu et al.

Summary: Immune checkpoint molecules, crucial for controlling immune responses, have been studied extensively and show promise in cancer therapy. A newly discovered cosignaling network involving various immune checkpoint receptors has the potential to enhance cancer immunotherapy by stimulating or inhibiting NK and T cell activation.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Immunology

PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-alpha Production and Restricts Progression of Metastatic Melanoma

Emily Howard et al.

Summary: Inhibition of PD-1 on ILC2s suppresses B16 tumor growth and upregulates the production of TNF-alpha, inducing cell death in B16 cells independent of adaptive immunity. These results emphasize the important anti-tumor role of ILC2s in pulmonary B16 cancer progression during PD-1 inhibitory immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

Article Cell Biology

CD226: An Emerging Role in Immunologic Diseases

Zhiyi Huang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Multidisciplinary Sciences

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

Doumet Georges Helou et al.

NATURE COMMUNICATIONS (2020)

Article Immunology

CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model

Ning Wang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Immunology

ICAM-1 controls development and function of ILC2

Ai-Hua Lei et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Article Allergy

Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers

Mohamed H. Shamji et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Immunology

Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in Allergic Airway Inflammation

Bobby W. S. Li et al.

FRONTIERS IN IMMUNOLOGY (2017)

Review Allergy

Sublingual or subcutaneous immunotherapy for allergic rhinitis?

Stephen R. Durham et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

Expression of DNAM-1 (CD226) on inflammatory monocytes

Anh Van Vo et al.

MOLECULAR IMMUNOLOGY (2016)

Review Primary Health Care

Allergic Rhinitis

Hasan A. Kakli et al.

PRIMARY CARE (2016)

Article Medicine, General & Internal

Allergic Rhinitis

Lisa M. Wheatley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Otorhinolaryngology

Clinical Practice Guideline: Allergic Rhinitis

Michael D. Seidman et al.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY (2015)

Review Cell Biology

At the Bench: Understanding group 2 innate lymphoid cells in disease

Taylor A. Doherty

JOURNAL OF LEUKOCYTE BIOLOGY (2015)

Article Multidisciplinary Sciences

Caerulomycin A inhibits Th2 cell activity: a possible role in the management of asthma

Weshely Kujur et al.

SCIENTIFIC REPORTS (2015)

Review Otorhinolaryngology

Epidemiology of allergic rhinitis

James W. Mims

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2014)

Article Multidisciplinary Sciences

Type 2 innate lymphoid cells control eosinophil homeostasis

Jesse C. Nussbaum et al.

NATURE (2013)

Article Medicine, General & Internal

Allergic rhinitis

Alexander N. Greiner et al.

LANCET (2011)

Article Multidisciplinary Sciences

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

Daniel R. Neill et al.

NATURE (2010)

Article Genetics & Heredity

CD226 Gly307Ser association with multiple autoimmune diseases

J. P. Hafler et al.

GENES AND IMMUNITY (2009)

Article Allergy

Burden of allergic rhinitis: Results from the Pediatric Allergies in America survey

Eli O. Meltzer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2) - A novel interface in the allergic process

Ido Bachelet et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Immunology

All roads lead to Rome: pathways of NKT cells promoting asthma

Tan Jinquan et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2006)