Study of carboxymethyl cellulose (CMC) coated manganite as potential candidate for magnetic hyperthermia applications

The present study reports substantial coating of biocompatible polymer Carboxymethyl Cellulose (CMC) on magnetic nanoparticles (MNPs) of Lanthanum Strontium Manganese Oxide (LSMO) also called manganite, as a novel attempt, for magnetic Hyperthermia applications. Two series of manganite (La1-xSrxMnO3) were synthesized through Citrate-gel technique choosing x as (0.3) and (0.33). X-ray diffraction (XRD) study has shown satisfactory phase formation of MNPs in accordance with the standard patterns. High resolution transmission electron microscopy (HRTEM) was done to evaluate the effect of CMC on particles' morphology after coating. The Fourier transform infrared spectroscopy (FTIR) has displayed successful attachment of CMC on the surface of MNPs and adsorbed coating amounts have been assessed through Thermogravimetric analysis and Differential Scanning Calorimetry (TGA/DSC). The coated LSMO were dispersed in Phosphate Buffer Saline (PBS, pH = 7) as an innovative try, to see the potential of these mediators towards effective Hyperthermia applications in fluid form at a suitable frequency of the applied magnetic field. The CMC coated MNPs have achieved quite appreciable specific absorption rate (SAR) up to 225 W/g and intrinsic loss power (ILP); showing a positive sign for their possible usage in Hyperthermia therapy.

Automated summary

The present study successfully coated biocompatible polymer CMC on magnetic nanoparticles LSMO for magnetic hyperthermia applications. The coated LSMO showed high specific absorption rate and intrinsic loss power, indicating their potential usage in hyperthermia therapy.