4.7 Article

Spongenolactones A-C, Bioactive 5,5,6,6,5-Pentacyclic Spongian Diterpenes from the Red Sea Sponge Spongia sp.

Journal

MARINE DRUGS
Volume 20, Issue 8, Pages -

Publisher

MDPI
DOI: 10.3390/md20080498

Keywords

Red Sea sponge; Spongia sp; 5; 5; 6; 6; 5-pentacyclic spongian diterpenes; anti-inflammatory assay; antibacterial assay

Funding

  1. National Sun Yat-sen University Kaohsiung Medical University [NSYSUKMU 109-I002, 110-P016]
  2. Ministry of Science and Technology of Taiwan [MOST 108-2320-B-110-003-MY2, 110-2320-B-110-001]

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Three new 5,5,6,6,5-pentacyclic spongian diterpenes were isolated from a Red Sea sponge. They exhibited inhibitory activity against superoxide anion generation, antibacterial properties, and anti-inflammatory effects, with one compound showing higher inhibition against Staphylococcus aureus.
Three new 5,5,6,6,5-pentacyclic spongian diterpenes, spongenolactones A-C (1-3), were isolated from a Red Sea sponge Spongia sp. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and the absolute configurations of 1-3 were determined on the basis of comparison of the experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra. Compounds 1-3 are the first 5,5,6,6,5-pentacyclic spongian diterpenes bearing an beta-hydroxy group at C-1. These metabolites were assayed for their cytotoxic, antibacterial, and anti-inflammatory activities. All three compounds were found to exert inhibitory activity against superoxide anion generation in fMLF/CB-stimulated human neutrophils. Furthermore, 1 showed a higher activity against the growth of Staphylococcus aureus in comparison to 2.

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