The Ameliorative Effect of COST on Diet-Induced Lipid Metabolism Disorders by Regulating Intestinal Microbiota

Background: Chitosan oligosaccharides, with an average molecular weight <= 1000 Da (COST), is a natural marine product that has the potential to improve intestinal microflora and resist lipid metabolism disorders. Methods: First, by establishing a mice model of lipid metabolism disorder induced by a high fat and high sugar diet, it is proven that COST can reduce lipid metabolism disorder, which may play a role in regulating intestinal microorganisms. Then, the key role of COST in the treatment of intestinal microorganisms is further confirmed through the method of COST-treated feces and fecal bacteria transplantation. Conclusions: intestinal microbiota plays a key role in COST inhibition of lipid metabolism disorder induced by a high fat and high sugar diet. In particular, COST may play a central regulatory role in microbiota, including Bacteroides, Akkermansia, and Desulfovibrio. Taken together, our work suggests that COST may improve the composition of gut microbes, increase the abundance of beneficial bacteria, improve lipid metabolism disorders, and inhibit the development of metabolic disorders.

Automated summary

Chitosan oligosaccharides with low molecular weight (COST) is a natural product that can improve intestinal microflora and resist lipid metabolism disorders. Experiments have shown that COST can reduce lipid metabolism disorders and regulate intestinal microorganisms. The regulatory role of COST in intestinal microorganisms may play a central role in improving gut microbe composition, increasing beneficial bacteria abundance, improving lipid metabolism disorders, and inhibiting the development of metabolic disorders.