Journal
MARINE DRUGS
Volume 20, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/md20060378
Keywords
oncolytic vaccinia virus; viral replication; Aphrocallistes vastus lectin; Huh7 cells
Categories
Funding
- National Natural Science Foundation of China [81972281]
- Natural Science Foundation of Zhejiang Province [LGF22C010005]
- Hangzhou Gongchu Biotechnology Co., Ltd.
Ask authors/readers for more resources
The oncolytic vaccinia virus containing Aphrocallistes vastus lectin (oncoVV-AVL) has shown significant anti-tumor effects in hepatocellular carcinoma. The virus activates tumor immunity by upregulating type I interferon expression and enhances replication by inhibiting ISRE mediated viral defense response. Furthermore, the lectin regulates multiple signaling pathways to promote virus replication.
Oncolytic vaccinia virus has been developed as a novel cancer therapeutic drug in recent years. Our previous studies demonstrated that the antitumor effect of oncolytic vaccina virus harboring Aphrocallistes vastus lectin (oncoVV-AVL) was significantly enhanced in several cancer cells. In the present study, we investigated the underlying mechanisms of AVL that affect virus replication and promote the antitumor efficacy of oncolytic virus in hepatocellular carcinoma (HCC). Our results showed that oncoVV-AVL markedly exhibited antitumor effects in both hepatocellular carcinoma cell lines and a xenograft mouse model. Further investigation illustrated that oncoVV-AVL could activate tumor immunity by upregulating the expression of type I interferons and enhance virus replication by inhibiting ISRE mediated viral defense response. In addition, we inferred that AVL promoted the ability of virus replication by regulating the PI3K/Akt, MAPK/ERK, and Hippo/MST pathways through cross-talk Raf-1, as well as metabolism-related pathways. These findings provide a novel perspective for the exploitation of marine lectins in oncolytic therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available