Journal
LIPIDS IN HEALTH AND DISEASE
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12944-022-01679-x
Keywords
Fat distribution; Plasma triglycerides; Adipose tissue; Oral fat tolerance test; Ethnicity; Cardiovascular disease; Type 2 diabetes
Funding
- Lund University (ALF grants) [20101641, 20101837, 162641]
- Swedish Research Council [LUDC 349-2006-237, Exodiab 2009-IRC15-0067]
- Skane University
- Lund University
Ask authors/readers for more resources
This study suggests that early signs of disturbed fat metabolism in Middle Eastern immigrants without cardiovascular disease risk factors are primarily reflected in elevated postprandial plasma triglyceride levels, rather than differences in fat distribution.
Purpose Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Methods This observational study included 26 Iraqi and 16 Swedish-born men without T2D or clinical risk factors for CVD. An oral fat tolerance test (OFTT) was performed, where plasma triglycerides (p-TG) were measured for 6 h. mRNA expression and adipocyte size were measured in subcutaneous adipose tissue biopsies collected prior to OFTT, and magnetic resonance imaging was conducted to assess body fat distribution. Results The median p-TG accumulation was higher and the clearance slower among Iraqis than Swedes. None of the groups reached their fasting p-TG (Iraqis 1.55 mmol/l; Swedes 0.95 mmol/l) after 6 h (Iraqis p-TG 3.10 mmol/l; Swedes p-TG 1.50 mmol/l). Adipocyte size, mRNA expression, and fat accumulation in the liver, muscle and abdomen were similar in both groups. Conclusion Postprandial p-TG levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants without CVD risk factors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available