An Active Group with Potential Anti-seizure Activity: A Review on 1,2,4-Triazoles

Background Epilepsy is one of the most common neurological disorders. Many individuals continue to have seizures despite medical and surgical treatments, suggesting that the discovery of novel anti-seizure drugs is vital. Triazole compounds are widely used as pharmaceuticals and have gained significant interest in medicinal chemistry. In this article, the development of triazoles, especially 1,2,4-triazole, in the field of anti-seizure therapeutics is reviewed. Methods The relevant literature was investigated, classified, and analysed. This article attempts to systematically review the research of triazole derivatives in the design and development of anti-seizure agents during the past two decades through extensive literature research, which was based on the information accessible in PubMed, Science Direct, Google Scholar and other databases. Results Research results demonstrate that triazoles occupy a distinct niche in heterocyclic chemistry and represent a key motif in medicinal chemistry because of their ability to exhibit an array of properties and bioactivities. Therefore, 1,2,4-triazole appears to be an important pharmacophore, especially in the field of anti-seizure therapeutics, where its promising potential value has been explored. Conclusion This review presents a summary of the research related to 1,2,4-triazole, which acts as a potential anti-seizure pharmacophore that could be further developed. Compounds with 1,2,4-triazole or related structures had previously shown reasonable anti-seizure activity and safety. After thorough research of this structure, it is believed that 1,2,4-triazole-containing compounds will be further developed as anti-seizure drugs for clinical use.

Automated summary

This article provides a systematic review of the research on 1,2,4-triazole in the field of anti-seizure therapeutics. The results demonstrate that 1,2,4-triazole occupies a unique position in heterocyclic chemistry and represents an important motif in medicinal chemistry due to its ability to exhibit diverse properties and bioactivities. Therefore, 1,2,4-triazole has promising potential value in the field of anti-seizure therapeutics.