4.7 Article

Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension

Related references

Note: Only part of the references are listed.
Review Genetics & Heredity

Genetics meets proteomics: perspectives for large population-based studies

Karsten Suhre et al.

Summary: The integration of genetics and plasma proteomics provides insights into human disease, revealing connections between genetic and non-genetic risk factors with clinical outcomes. Proteomic analysis offers valuable information on disease mechanisms, clinical biomarkers, and therapeutic opportunities, highlighting the potential for discovering novel drug targets and translational biomarkers through association studies.

NATURE REVIEWS GENETICS (2021)

Article Biochemistry & Molecular Biology

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions

Rose Oughtred et al.

Summary: BioGRID is an open-access database resource that houses protein and genetic interactions from multiple species, serving as a tool for building complex networks to facilitate biomedical discoveries. Curated from primary experimental evidence, BioGRID captures both low-throughput and large high-throughput studies, including protein post-translational modifications and interactions with bioactive small molecules. Additionally, it undertakes themed curation projects in specific aspects of cellular regulation and disease areas.

PROTEIN SCIENCE (2021)

Article Genetics & Heredity

A cross-platform approach identifies genetic regulators of human metabolism and health

Luca A. Lotta et al.

Summary: By conducting a cross-platform analysis of metabolites, we identified various genetic regulators associated with metabolite levels, including their impact on diseases such as type 2 diabetes and macular telangiectasia type 2.

NATURE GENETICS (2021)

Article Multidisciplinary Sciences

Mapping the proteo-genomic convergence of human diseases

Maik Pietzner et al.

Summary: The study identified genetic associations for plasma proteins and established a map connecting genes, proteins, and diseases, highlighting biological convergence across diseases. This proteo-genomic map helps to understand relationships between diseases and provide biological context for emerging disorders.

SCIENCE (2021)

Article Urology & Nephrology

Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension

Shengyuan Luo et al.

Summary: The study conducted extensive metabolite profiling in African Americans with chronic kidney disease, identifying novel genome-wide metabolite associations and providing insights into the key roles of enzymes in modulating systemic levels of metabolites.

KIDNEY INTERNATIONAL (2021)

Article Urology & Nephrology

Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

Insa M. Schmidt et al.

Summary: Analysis of gene expression profiles and the development of Luminex-based assays were used to identify promising non-invasive biomarkers of kidney fibrosis. CDH11, SMOC2, and PEDF were found to be associated with the severity of interstitial fibrosis and tubular atrophy, as well as progression to end-stage kidney disease in independent cohorts of chronic kidney disease patients.

KIDNEY INTERNATIONAL (2021)

Article Multidisciplinary Sciences

Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals

Kira J. Stanzick et al.

Summary: Identifying causal variants and genes for kidney function in genome-wide association studies remains challenging, but can be aided by larger sample sizes. Meta-analysis of GWAS for kidney function identified new loci and fine-mapped variants and genes, shedding light on the complex genetic architecture underlying kidney function. Fine-mapping also revealed specific associations with cystatin-based eGFR and blood urea nitrogen levels at multiple loci.

NATURE COMMUNICATIONS (2021)

Review Cardiac & Cardiovascular Systems

Importance of Genetic Studies of Cardiometabolic Disease in Diverse Populations

Lindsay Fernandez-Rhodes et al.

CIRCULATION RESEARCH (2020)

Article Statistics & Probability

A simple new approach to variable selection in regression, with application to genetic fine mapping

Gao Wang et al.

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY (2020)

Article Multidisciplinary Sciences

Circulating testican-2 is a podocyte-derived marker of kidney health

Debby Ngo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Genetic architecture of host proteins involved in SARS-CoV-2 infection

Maik Pietzner et al.

NATURE COMMUNICATIONS (2020)

Article Endocrinology & Metabolism

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Lasse Folkersen et al.

NATURE METABOLISM (2020)

Article Multidisciplinary Sciences

Genetic analyses of diverse populations improves discovery for complex traits

Genevieve L. Wojcik et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

Annalisa Buniello et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Genetics & Heredity

From genome-wide associations to candidate causal variants by statistical fine-mapping

Daniel J. Schaid et al.

NATURE REVIEWS GENETICS (2018)

Article Genetics & Heredity

An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome

Christopher E. Gillies et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2018)

Article Multidisciplinary Sciences

Genomic atlas of the human plasma proteome

Benjamin B. Sun et al.

NATURE (2018)

Article Multidisciplinary Sciences

Co-regulatory networks of human serum proteins link genetics to disease

Valur Emilsson et al.

SCIENCE (2018)

Article Genetics & Heredity

An atlas of genetic associations in UK Biobank

Oriol Canela-Xandri et al.

NATURE GENETICS (2018)

Article Multidisciplinary Sciences

Connecting genetic risk to disease end points through the human blood plasma proteome

Karsten Suhre et al.

NATURE COMMUNICATIONS (2017)

Article Urology & Nephrology

RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis

Florin L. Craciun et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Article Genetics & Heredity

Next-generation genotype imputation service and methods

Sayantan Das et al.

NATURE GENETICS (2016)

Article Multidisciplinary Sciences

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

Kristin G. Ardlie et al.

SCIENCE (2015)

Article Biotechnology & Applied Microbiology

The Ensembl Regulatory Build

Daniel R. Zerbino et al.

GENOME BIOLOGY (2015)

Article Biochemical Research Methods

SNiPA: an interactive, genetic variant-centered annotation browser

Matthias Arnold et al.

BIOINFORMATICS (2015)

Article Multidisciplinary Sciences

Fast Association Tests for Genes with FAST

Pritam Chanda et al.

PLOS ONE (2013)

Letter Genetics & Heredity

Long-range LD can confound genome scans in admixed populations

Alkes L. Price et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2008)

Article Genetics & Heredity

Principal components analysis corrects for stratification in genome-wide association studies

Alkes L. Price et al.

NATURE GENETICS (2006)

Article Urology & Nephrology

The rationale and design of the AASK Cohort Study

LJ Appel et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)

Article Biochemistry & Molecular Biology

Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function

PCY Liaw et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)