4.7 Article

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19: a meta-analysis

Wen Wen et al.

Summary: This study conducted a meta-analysis on three new oral antivirals (molnupiravir, fluvoxamine, and Paxlovid) and their effects on mortality and hospitalization rates among COVID-19 patients. The results showed that these drugs were effective in reducing mortality and hospitalization rates by approximately 67%. Furthermore, the drugs did not increase adverse events, indicating good overall safety.

ANNALS OF MEDICINE (2022)

Review Pharmacology & Pharmacy

Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety

Peter Breining et al.

Summary: Camostat mesylate is a potent inhibitor of the serine protease TMPRSS2, effectively hindering virus-cell membrane fusion and replication, reducing viral load, and potentially improving patient outcomes. Ongoing clinical trials are investigating its potential as an antiviral agent against COVID-19.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2021)

Article Medicine, General & Internal

First Case of 2019 Novel Coronavirus in the United States

Michelle L. Holshue et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Letter Microbiology

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

Markus Hoffmann et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

Letter Medicine, General & Internal

Camostat mesilate therapy for COVID-19

Yoshiharu Uno

INTERNAL AND EMERGENCY MEDICINE (2020)

Review Biochemistry & Molecular Biology

COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives

Jiumeng Sun et al.

TRENDS IN MOLECULAR MEDICINE (2020)

Article Medicine, General & Internal

Compassionate Use of Remdesivir for Patients with Severe Covid-19

J. Grein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Immunology

Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2

Jianhui Nie et al.

EMERGING MICROBES & INFECTIONS (2020)

Article Oncology

Ovarian Cancer Statistics, 2018

Lindsey A. Torre et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Review Biotechnology & Applied Microbiology

Coronaviruses - drug discovery and therapeutic options

Alimuddin Zumla et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Pharmacology & Pharmacy

Protease inhibitors targeting coronavirus and filovirus entry

Yanchen Zhou et al.

ANTIVIRAL RESEARCH (2015)

Article Chemistry, Multidisciplinary

AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility

Garrett M. Morris et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)

Article Pharmacology & Pharmacy

Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction

Tin-Yun Ho et al.

ANTIVIRAL RESEARCH (2007)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)