Journal
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Volume 103, Issue 1, Pages 26-36Publisher
WILEY
DOI: 10.1002/jsfa.12121
Keywords
response surface methodology; optimization; bioactive compounds; experimental design; extraction process
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This paper reviews the use of response surface methodology (RSM) in modeling and optimizing the extraction process of bioactive compounds. It discusses the optimization approach, experimental design, empirical models, and challenges associated with RSM, while highlighting recent studies and applications.
Response surface methodology (RSM) is a widely used mathematical and statistical technique for modeling and optimizing the process for the extraction of bioactive compounds. This review explains the optimization approach through the use of experimental design and empirical models for response prediction and the utilization of the desirability function for multiple response optimization. This paper also reviews recent studies on the application of RSM to optimize bioactive compound extraction processes such as conventional solvent extraction, microwave-assisted extraction, supercritical fluid extraction, and ultrasound-assisted extraction. Finally, the challenges associated with the use of RSM and the efforts made to improve RSM in the extraction process are also highlighted. Overall, this review informs many aspects of RSM that are occasionally ignored or insufficiently discussed with regard to the optimization of bioactive compound extraction processes, and it summarizes significant applications where RSM proved suitable. (c) 2022 Society of Chemical Industry.
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