Inflammasome Signaling in Atrial Fibrillation JACC State-of-the-Art Review

As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in patients with cardiovascular diseases. Despite the multi-faceted nature of AF pathogenesis and complexity of AF pathophysiology, a growing body of evidence indicates that the NLRP3 inflammasome activation contributes to onset and progression of AF. Herein, the authors aim at reviewing the current literature on the role of inflammasome signaling in AF pathogenesis, and novel therapeutic options in the management of AF. (C) 2022 by the American College of Cardiology Foundation.

Automated summary

Atrial fibrillation, the most prevalent form of arrhythmia, increases the risk of heart failure, thromboembolism, and stroke. Activation of the NLRP3 inflammasome is associated with the onset and progression of atrial fibrillation.