Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 79, Issue 24, Pages 2431-2449Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2022.04.015
Keywords
cocaine; MINOCA; premature myocardial infarction; SCAD; smoking
Categories
Funding
- Amgen
- ELPEN
- Sanofi
- Mylan
- Novartis
- Servier
- Bayer Hellas
- Boston Scientific
- GE Healthcare
- Abbott
- Edwards Lifesciences
- Daiichi-Sankyo
- Concept Medical
- National Institutes of Health
- Boehringer Ingelheim
- CSL Behring
- Ferring Pharmaceuticals
- Bayer
Ask authors/readers for more resources
The proportion of young individuals with acute myocardial infarction (AMI) has increased in recent years. Despite less extensive coronary atherosclerosis, young AMI patients still have poor long-term prognosis. They share similar risk factors with older patients for obstructive coronary artery disease, except for higher prevalence of smoking, lipid disorders, and family history of premature coronary artery disease, and lower prevalence of diabetes mellitus and hypertension. Nonobstructive coronary artery myocardial infarction is relatively common among young AMI patients, requiring specific diagnostic and treatment approaches.
Among patients presenting with acute myocardial infarction (AMI), the proportion of young individuals has increased in recent years. Although coronary atherosclerosis is less extensive in young patients with AMI, with higher prevalence of single-vessel disease and rare left main involvement, the long-term prognosis is not benign. Young patients with AMI with obstructive coronary artery disease have similar risk factors as older patients except for higher prevalence of smoking, lipid disorders, and family history of premature coronary artery disease, and lower prevalence of diabetes mellitus and hypertension. Smoking cessation is by far the most effective secondary preventive measure. Myocardial infarction with nonobstructive coronary arteries is a relatively common clinical entity (10%-20%) among young patients with AMI, with intravascular and cardiac magnetic resonance imaging being key for diagnosis and potentially treatment. Spontaneous coronary artery dissection is a frequent pathogenetic mechanism of AMI among young women, requiring a high degree of suspicion, especially in the peripartum period. (C) 2022 by the American College of Cardiology Foundation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available