Mitral Valve Dysfunction in Patients With Annular Calcification

Mitral annular calcification (MAC) is a common clinical finding and is associated with adverse clinical outcomes, but the clinical impact of MAC-related mitral valve (MV) dysfunction remains underappreciated. Patients with MAC frequently have stenotic, regurgitant, or mixed valvular disease, and this valvular dysfunction is increasingly recognized to be independently associated with worse prognosis. MAC-related MV dysfunction is a distinct pathophysiologic entity, and importantly much of the diagnostic and therapeutic paradigm from published rheumatic MV disease research cannot be applied in this context, leaving important gaps in our knowledge. This review summarizes the current epidemiology, pathophysiology, diagnosis, and classification of MAC-related MV dysfunction and proposes both an integrative definition and an overarching approach to this important and increasingly recognized clinical condition. (J Am Coll Cardiol 2022;80:739-751) (C) 2022 by the American College of Cardiology Foundation.

Automated summary

Mitral annular calcification is associated with adverse clinical outcomes, and its impact on mitral valve dysfunction is underestimated. This review summarizes the epidemiology, pathophysiology, diagnosis, and classification of MAC-related MV dysfunction and proposes an integrative definition and approach to this clinical condition.