Preparation and in vivo imaging of a novel potential αvβ3 targeting PET/MRI dual-modal imaging agent

Multi-modal biomedical imaging has played an essential role in tumor diagnosis. However, constructing a multi-modal imaging contrast agent with high affinity to a tumor is challenging. Herein, we studied the design and application of a PET/MRI dual-modal imaging agent based on superparamagnetic iron oxide nanoparticles (SPION). alpha(v)beta(3)-targeting RGD peptide and Cu-64 were conjugated onto SPION. Small animal PET and MR imaging in glioblastoma tumor-bearing mice revealed that this dual-modal imaging contrast agent could potentially be utilized for PET/MRI dual-modal imaging for the tumor diagnosis.

Automated summary

In this study, we investigated the design and application of a PET/MRI dual-modal imaging agent based on superparamagnetic iron oxide nanoparticles (SPION). The α(v)β(3)-targeting RGD peptide and Cu-64 were conjugated onto SPION. Small animal PET and MR imaging in glioblastoma tumor-bearing mice showed that this dual-modal imaging contrast agent could potentially be used for PET/MRI dual-modal imaging for tumor diagnosis.