4.6 Article

Nanogold-capped poly(DEGDMA) microparticles as surface-enhanced Raman scattering substrates for DNA detection

Journal

JOURNAL OF PHYSICS D-APPLIED PHYSICS
Volume 55, Issue 40, Pages -

Publisher

IOP Publishing Ltd
DOI: 10.1088/1361-6463/ac7bba

Keywords

surface-enhanced Raman scattering (SERS); Raman spectroscopy; gold nanoparticles; gamma-radiation initiated polymerization; polymeric microparticles; rhodamine 6G; biosensing

Funding

  1. Stipendium Hungaricum Scholarship Programme
  2. National Research, Development and Innovation Fund of Hungary [NVKP_16-1-2016-0043, VEKOP-2.3.2-16-2016-00011]
  3. European Union
  4. European Social Fund
  5. Nanoplasmonic Laser Fusion Research Laboratory project - National Research and Innovation Office (NKFIH)
  6. Eotvos Roland Research Network (ELKH), Hungary

Ask authors/readers for more resources

A novel platform for surface-enhanced Raman scattering (SERS) was developed by decorating diethylene glycol dimethacrylate microparticles with gold nanoparticles, resulting in significant enhancement of the Raman signal. Near-infrared excitation at 532, 633, and 785 nm exhibited the highest enhancement on the substrate, which also showed excellent temporal stability and spatial uniformity. The practical application potential of this SERS substrate was demonstrated by detecting DNA sequences.
A novel platform for surface-enhanced Raman scattering (SERS) was fabricated consisting of diethylene glycol dimethacrylate microparticles prepared by gamma-radiation initiated polymerization and decorated with gold nanoparticles. The comparison of bare and decorated microparticles shows significant SERS enhancement in the Raman signal of rhodamine 6G on the latter. For 532, 633 and 785 nm excitations the near-infrared one was found to show the highest enhancement on the substrate, which also showed excellent temporal stability and spatial uniformity. The practical application potential of the SERS substrate is demonstrated with the detection of deoxyribonucleic acid sequences.

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