Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 13, Issue 31, Pages 7336-7341Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.2c01659
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Funding
- National Natural Science Foundation of China [32000882]
- USTC Research Funds of the Double First-Class Initiative [YD2030002006]
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This study reveals the counterintuitive cooperation phenomenon among motor proteins in intracellular transport and verifies the accuracy of the model. The results indicate that cooperation can significantly increase the transport distance, rationalizing the choice of bidirectional transport in evolution. Furthermore, the study derives the exact analytical solution for the transport distance.
In intracellular transport, the cargo is usually simultaneously carried by two types of motor proteins that move oppositely, widely described as a tug-of-war. We show theoretically that apart from the apparent competition, there is also a unintuitive cooperation between motors with opposite directionality. The model reproduces the in vivo experimental data with high accuracy. Under certain conditions, the cooperation can significantly increase the transport distance, rationalizing the choice of bidirectional over unidirectional transport in evolution. We further derive the exact analytical solution for the transport distance. Our results pave the road to understanding the physical nature of intracellular transport by motor proteins.
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