Journal
JOURNAL OF PHYSICAL CHEMISTRY C
Volume 126, Issue 25, Pages 10429-10440Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcc.2c01423
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This study reports the evidence of emissive aggregates of push-pull phenothiazine and phenothiazine dioxide derivatives. These aggregates show promise for applications in biology and material science. The study investigates the aggregation-induced emission (AIE) mechanism through time-resolved spectroscopy and advanced data analysis. The results demonstrate significant AIE behavior activated by the restriction of intramolecular rotations. The aggregates also exhibit notable emission upon two-photon excitation and have potential as novel fluorophores for bioimaging.
In this study, we report evidence for emissive aggregates of push-pull phenothiazine and phenothiazine dioxide derivatives produced both in water dispersions and in the solid state, highly promising for applications in both biology and material science. An insightful investigation of the aggregation-induced emission (AIE) mechanism was carried out via time-resolved spectroscopies, with nanosecond and femtosecond temporal resolution, coupled with advanced data analysis. Our steady-state and time-resolved spectroscopic results unambiguously show that a significant AIE behavior is activated by the restriction of intramolecular rotations for the phenothiazine derivatives. Investigation of the nonlinear optical properties also revealed that aggregates exhibit notable emission upon two-photon excitation. In particular, the phenothiazine dioxide-based aggregates exhibit remarkable fluorescence efliciencies and large two-photon absorption cross sections, as well as the capability to be internalized in HeLa cells exerting no cytotoxic efl'ect. These aggregate species thus prove to be promising as novel fluorophores for bioimaging.
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