Synthesis of β-Arylseleno Sulfoximines: A Metal-Free Three-Component Reaction Mediated by Tetrabutylammonium Tribromide

A tetrabutylammonium tribromide-mediated three-component reaction of alkenes, diselenides, and sulfoximines has been established herein, providing direct and metal-free access to diverse beta-arylseleno sulfoximine derivatives. This regioselective sulfoximido-selenization protocol proceeds efficiently under mild and ambient conditions with generally good yields. This strategy is featured by step and atom economy, practicability, a broad substrate scope, and gram-scale synthesis.

Automated summary

In this study, a tetrabutylammonium tribromide-mediated three-component reaction of alkenes, diselenides, and sulfoximines was established, providing a direct and metal-free access to diverse beta-arylseleno sulfoximine derivatives. This regioselective sulfoximido-selenization protocol proceeds efficiently under mild and ambient conditions with generally good yields. The strategy is characterized by step and atom economy, practicability, a broad substrate scope, and gram-scale synthesis.