A Mild and Regioselective Route to Fluoroalkyl Aromatic Compounds via Directed Cycloaddition Reactions

ABSTRACT: The synthesis of perfluoroalkyl-substituted (hetero)arenes by benzannulation strategies is complementary to ring functionalization approaches as it obviates the need for preexisting functionality and innate regiocontrol. We report a mild and regiospecific borondirected benzannulation method as a vehicle for accessing a range of perfluoroalkyl-substituted (hetero)aromatic building blocks that can be readily elaborated through established C-B bond functionalization processes.

Automated summary

We report a mild and regiospecific boron-directed benzannulation method for accessing a range of perfluoroalkyl-substituted (hetero)aromatic building blocks, which can be easily elaborated through established C-B bond functionalization processes.