Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 87, Issue 16, Pages 10698-10709Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c00884
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- National Natural Science Foundation of China [21801177]
- Science and Technology Department of Sichuan Province in China [2022YFS0005]
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A remote directing group-enabled radical relay strategy for benzylic direct C(sp3)-H alkoxylation with alcohols at room temperature is developed, which achieves satisfactory site-selectivity, chemoselectivity, and reaction scope under simple and mild conditions without the need for ligands or additives.
Employing a low loading of the terminal oxidant, a remote directing group-enabled radical relay strategy for benzylic direct C(sp3)-H alkoxylation with alcohols at room temperature is developed. Satisfactory site-selectivity, chemoselectivity, and reaction scope are achieved under simple and mild conditions, and no ligand or additive is required. Mechanistic studies, ready conversions of the directing group, and other benzylic functionalizations currently under development in our laboratory further indicate the promising potentials of this remote directing group-enabled radical relay strategy.
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