4.7 Article

Dysregulation of peripheral monocytes and pro-inflammation of alpha-synuclein in Parkinson's disease

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease

Sara Konstantin Nissen et al.

Summary: This study found that sCD163 in the CSF of PD patients correlated with PD biomarkers and cognition scores, supporting monocyte involvement in neurodegeneration and cognition in PD. An increase in CSF-sCD163 in female patients suggested a sex-distinctive monocyte response. In vitro studies showed the potential connection between CD163 and alpha-synuclein, indicating a role for monocytes in both peripheral and brain immune responses to PD.

MOVEMENT DISORDERS (2021)

Review Clinical Neurology

Periphery and brain, innate and adaptive immunity in Parkinson's disease

Ashley S. Harms et al.

Summary: Parkinson's disease involves both neuronal events and a significant immune component, with changes in the immune system occurring in both the central nervous system and the periphery. Alpha-synuclein plays a crucial role in activating the innate and adaptive immune system, contributing to neuronal degeneration and symptomatology in patients.

ACTA NEUROPATHOLOGICA (2021)

Review Biochemistry & Molecular Biology

Inflammasomes as therapeutic targets in human diseases

Yangxin Li et al.

Summary: Inflammasomes, as protein complexes in the innate immune system, play a dual role in diseases, with outcomes that can be either beneficial or detrimental depending on the disease and genetic background. The concept of inflammasome memory and the two-shot activation process are highlighted, along with the proposed M- and N-type inflammation models for targeting the inflammasome pathway in novel therapy development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Biochemistry & Molecular Biology

Constitutive Inflammatory Cytokine Storm: A Major Threat to Human Health

Krishna Kant Gupta et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2020)

Article Immunology

Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease

Ruwani S. Wijeyekoon et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

Review Immunology

Human Monocyte Subset Distinctions and Function: Insights From Gene Expression Analysis

Sarah Cormican et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Geriatrics & Gerontology

Inflammation in mild cognitive impairment due to Parkinson's disease, Lewy body disease, and Alzheimer's disease

Eleanor King et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2019)

Article Clinical Neurology

Alterations in Blood Monocyte Functions in Parkinson's Disease

Sara Konstantin Nissen et al.

MOVEMENT DISORDERS (2019)

Article Immunology

Abnormalities of age-related T cell senescence in Parkinson's disease

C. H. Williams-Gray et al.

JOURNAL OF NEUROINFLAMMATION (2018)

Review Neurosciences

Microglia Response During Parkinson's Disease: Alpha-Synuclein Intervention

Sara A. Ferreira et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Article Cell Biology

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Richard Gordon et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Article Clinical Neurology

The Peripheral Inflammatory Response to Alpha-Synuclein and Endotoxin in Parkinson's Disease

Alice J. White et al.

FRONTIERS IN NEUROLOGY (2018)

Article Clinical Neurology

Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease

Jens B. Schroeder et al.

FRONTIERS IN NEUROLOGY (2018)

Article Clinical Neurology

Monocyte Function in Parkinson's Disease and the Impact of Autologous Serum on Phagocytosis

Ruwani S. Wijeyekoon et al.

FRONTIERS IN NEUROLOGY (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Extrastriatal spreading of microglial activation in Parkinson's disease: a positron emission tomography study

Tatsuhiro Terada et al.

ANNALS OF NUCLEAR MEDICINE (2016)

Article Immunology

Inflammatory profile in LRRK2-associated prodromal and clinical PD

Kathrin Brockmann et al.

JOURNAL OF NEUROINFLAMMATION (2016)

Review Clinical Neurology

MDS clinical diagnostic criteria for Parkinson's disease

Ronald B. Postuma et al.

MOVEMENT DISORDERS (2015)

Article Clinical Neurology

Inflammatory dysregulation of blood monocytes in Parkinson's disease patients

Veselin Grozdanov et al.

ACTA NEUROPATHOLOGICA (2014)

Article Genetics & Heredity

Association of Parkinson Disease with Structural and Regulatory Variants in the HLA Region

William T. Wissemann et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2013)

Article Clinical Neurology

Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease

Natalja Funk et al.

MOVEMENT DISORDERS (2013)

Review Medicine, Research & Experimental

Soluble CD163

Holger J. Moller

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2012)

Article Neurosciences

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

Lydia Alvarez-Erviti et al.

NEUROSCIENCE RESEARCH (2011)

Article Hematology

Nomenclature of monocytes and dendritic cells in blood

Loems Ziegler-Heitbrock et al.

BLOOD (2010)

Article Immunology

Peripheral cytokines profile in Parkinson's disease

M. Reale et al.

BRAIN BEHAVIOR AND IMMUNITY (2009)

Article Geriatrics & Gerontology

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

Andis Klegeris et al.

NEUROBIOLOGY OF AGING (2008)

Article Clinical Neurology

Microglial activation and dopamine terminal loss in early Parkinson's disease

Y Ouchi et al.

ANNALS OF NEUROLOGY (2005)