Spatial and temporal specificity of neuroestradiol provision in the songbird

Steroid hormones are often synthesized in multiple tissues, affect several different targets, and modulate numerous physiological endpoints. The mechanisms by which this modulation is achieved with temporal and spatial specificity remain unclear. 17 beta-estradiol for example, is made in several peripheral tissues and in the brain, where it affects a diverse set of behaviors. How is estradiol delivered to the right target, at the right time, and at the right concentration? In the last two decades, we have learned that aromatase (estrogen-synthase) can be induced in astrocytes following damage to the brain and is expressed at central synapses. Both mechanisms of estrogen provision confer spatial and temporal specificity on a lipophilic neurohormone with potential access to all cells and tissues. In this review, I trace the progress in our understanding of astrocytic and synaptic aromatization. I discuss the incidence, regulation, and functions of neuroestradiol provision by aromatization, first in astrocytes and then at synapses. Finally, I focus on a relatively novel hypothesis about the role of neuroestradiol in the orchestration of species-specific behaviors.

Automated summary

Steroid hormones, such as 17 beta-estradiol, can be synthesized in multiple tissues and affect various physiological endpoints. The mechanisms underlying the temporal and spatial specificity of their modulation remain unclear. This review highlights the role of aromatase in astrocytes and synapses in providing localized delivery of estradiol. The understanding of neuroestradiol provision and its potential involvement in species-specific behaviors is discussed.