Journal
JOURNAL OF NATURAL PRODUCTS
Volume 85, Issue 6, Pages 1486-1494Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.1c01155
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Funding
- Scientific Research Foundation of Yunnan Province Science and Technology Department [202201AY070001-009, 202201AY070001-010]
- National Natural Science Foundation of China [31860095]
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Cultivation of an endophytic fungus with a histone deacetylase inhibitor resulted in the isolation of new diterpenic meroterpenoids with unique natural product framework and moderate activity.
Cultivation of an endophytic fungus Penicillium sp. KMU18029 with suberanilohydroxamic acid (SAHA), a histone deacetylase inhibitor, led to the isolation of two pairs of diterpenic meroterpenoids with a unique natural product framework combining features of pyripyropenes and decaturins/oxalicines, pyrandecarurins A (1) and B (2), pileotin A (3) and B (4), along with their potential precursor decaturenoid (5). Compounds 1, 2, 4, and 5 were new. The structures of 1 -5 were elucidated by extensive spectroscopic analyses. The absolute configurations of 1 -4 were determined by single-crystal X-ray diffraction, NOESY spectra, ECD calculations, and biogenetic considerations. The absolute configuration of compound 3 was confirmed for the first time. Compound 5 showed moderate activity against AChE with an IC50 value of 13.9 +/- 1.1 mu M.
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