Journal
JOURNAL OF NATURAL PRODUCTS
Volume 85, Issue 6, Pages 1658-1664Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.1c01195
Keywords
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Funding
- Japan Society for the Promotion of Science KAKENHI [21K06619]
- National Natural Science Foundation of China [81872768]
- Shenyang Young Scientific and Technological Innovators Program [RC200408]
- Doctoral Scientific Research Foundation of Liaoning Province [2020-BS-129]
- United States National Institute of Allergy and Infectious Diseases (NIAID, NIH) [R01 AI165473]
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Tigliane-type diterpenoids have significant biological effects, including antineoplastic and anti-HIV activities. In this study, new tigliane-type diterpenoids were isolated from Wikstroemia lichiangensis for the first time, and their structures were determined. These compounds exhibited potent anti-HIV activity against HIV-1 infection.
Tigliane-type diterpenoids have attracted much attention in drug discovery since they have been reported to exhibit remarkable biological effects, such as tumor-promoting, antineoplastic, and anti-HIV activities. In continuing our efforts to discover novel biologically important diterpenoids from Wikstroemia species, Wikstroemia lichiangensis was investigated phytochemically for the first time. As a result, four new (1-4) and one known (5) tigliane-type diterpenoid were isolated, and their structures were elucidated by spectroscopic data analysis. Tiglianes (1-5) showed potent anti-HIV activity against HIV-1 infection of MT4 lymphocytes with IC50 values of 1.1-65.4 nM.
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