Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 94, Issue 11, Pages 5149-5162Publisher
WILEY
DOI: 10.1002/jmv.28028
Keywords
ABO; fucosyltransferase; FUT2; FUT3; glycosyltransferase; histo-blood group antigens; Lewis; secretor
Categories
Funding
- UGC institutional Fellowship
- Research Fund of the Department of Biotechnology [BT/338/NE/TBP/2012]
Ask authors/readers for more resources
Infectious gastroenteritis is a common illness worldwide. The viruses rotavirus and norovirus can attach to histo-blood group antigens (HBGAs) as receptors. Genetic variations in the genes encoding ABO, fucosyltransferase genes FUT2 (Secretor/Se) and FUT3 (Lewis/Le) can affect enzyme expression and production of HBGAs, influencing susceptibility or resistance to enteric pathogens.
Infectious gastroenteritis is a common illness afflicting people worldwide. The two most common etiological agents of viral gastroenteritis, rotavirus and norovirus are known to recognize histo-blood group antigens (HBGAs) as attachment receptors. ABO, Lewis, and secretor HBGAs are distributed abundantly on mucosal epithelia, red blood cell membranes, and also secreted in biological fluids, such as saliva, intestinal content, milk, and blood. HBGAs are fucosylated glycans that have been implicated in the attachment of some enteric pathogens such as bacteria, parasites, and viruses. Single nucleotide polymorphisms in the genes encoding ABO (H), fucosyltransferase gene FUT2 (Secretor/Se), FUT3 (Lewis/Le) have been associated with changes in enzyme expression and HBGAs production. The highly polymorphic HBGAs among different populations and races influence genotype-specific susceptibility or resistance to enteric pathogens and its epidemiology, and vaccination seroconversion. Therefore, there is an urgent need to conduct population-based investigations to understand predisposition to enteric infections and gastrointestinal diseases. This review focuses on the relationship between HBGAs and predisposition to common human gastrointestinal illnesses caused by viral, bacterial, and parasitic agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available