Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 553, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jmmm.2022.169278
Keywords
Magnetic nanoparticles; Nano-magnetomechanical activation; Brownian relaxation; Biomedicine
Funding
- RFBR (Russia) [18-29-09154]
- Lomonosov Moscow State University [AAAA-A21-121011290089-4]
- Ministry of Science and Higher Education of the Russian Federation [075-15-2021-709, RF-2296.61321X0037]
- Lomonosov Moscow State University development program [PNR 5.13]
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The study analyzes the parameters and conditions for mechanically influencing biological macromolecular structures using MNPs activated by low-frequency MF through nano-magnetomechanical approach, providing crucial theoretical results for biomedical applications.
Magnetic nanoparticles (MNPs) in biomedical applications can affect surrounding biomacromolecules mechanically, thermally, or both depending on amplitude and frequency of external alternating magnetic field (MF). Nano-magnetomechanical approach utilizes rotational oscillations of MNPs activated by non-heating low-frequency MF to affect bioactive macromolecules mechanically. In present paper, we analyze parameters and conditions that allow MNP's mechanical rotation and provide maximal mechanical forces applied to macromolecular structures such as bioactive molecules, addressed drug delivery nanocarriers or cells by alternating MF activated MNPs. Here, we formulate criteria for choice of various MNP-MF system parameters in regard to nanomagnetomechanical approach such as optimal ranges of MNP and associated macromolecules characteristics, MF frequency and induction enabling maximum nanomechanical effects. Theoretically obtained results are crucial for biomedical applications utilizing nanomechanical stimulation of biological targets by means of MNPs activated by alternating MF.
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