Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 233, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2022.111860
Keywords
Salicylaldehyde; Schiff base; Cobalt(II) complexes; Anticancer; Cell apoptosis; Substitution group effect
Funding
- National Natural Science Foundation of China [12064002, 22061004, 21901050]
- Guangxi Natural Science Foundation of China [2020GXNSFAA159132, 2018GXNSFBA050031]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal Uni-versity) [CMEMR2018-C8, CMEMR2017-A11]
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Schiff base and its complexes have great prospects in biological applications. This study reported four cobalt(II) complexes with bis-Schiff base ligands and screened their anti-tumor activities. Complex 3 showed the best anti-cancer effect and exhibited selectivity against cancer cell lines.
Schiff base and its complexes are being paid more and more interests for their great prospects in biological applications. We reported here four cobalt(II) complexes [Co-3(L-1)(2)(HCOO)(2)] (1), [Co-3(L-2)(2)(HCOO)(2)(CH3OH)(2)].2CH(3)OH (2), [Co-3(HL3)(2)(OAc)(2)(DMF)(2)] (3) and [Co-3(HL4)(2)(HCOO)(2)(DMF)(2)].2H(2)O (4) bearing the bis-Schiff base ligand of bis(5-bromosalicylidene)-1,3-propanediamine (H2L1), bis(5-bromosalicylidene)-2-methyl-1,3-propanediamine (H2L2), bis(5-chlorosalicylidene)-2-hydroxyl-1,3-propanediamine (H3L3) and bis(5-bromosalicylidene)-2-hydroxyl-1,3-propanediamine (H3L4), respectively. The anti-tumor activities of the four titled complexes were screened on a series of tumor cell lines. After an overall consideration of their cytotoxicity on cancer cells and normal cells in comparison to those for cisplatin, complex 3 shows the best anticancer effect among the four titled complexes. It revealed the influence of anti-cancer effects of the substitution groups of H, Me and OH, as well as Cl and Br. Anticancer selectivity was also found for complex 3 on different cancer cell lines with the lowest IC50 value on T-24 cells. Complex 3 induces cell apoptosis through mitochondrial pathway as demonstrated by increasing the level of reactive oxygen species, decreasing mitochondrial membrane potential, activating caspase 3/9 and arresting cell cycle in G1 phase.
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