4.7 Article

Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model

Related references

Note: Only part of the references are listed.
Article Immunology

Clostridioides difficile Whole-genome Sequencing Differentiates Relapse With the Same Strain From Reinfection With a New Strain

Janice Cho et al.

Summary: Through WGS analysis of C. difficile isolates from CDI patients, it was found that 40% of community-acquired CDI patients may have transmission within the same zip code. WGS better differentiates between relapse and reinfection than definitions based on the timing of recurrence.

CLINICAL INFECTIOUS DISEASES (2021)

Article Pharmacology & Pharmacy

Pharmacokinetics of CamSA, a potential prophylactic compound against Clostridioides difficile infections

Christopher Yip et al.

Summary: The synthetic bile salt CamSA shows potential in preventing Clostridioides difficile infections, offering multi-day protection with a single dose in mice. Its pharmacokinetic properties suggest limited systemic absorption and a slow-release mechanism through cycling between the liver and intestines. This unique pattern of protection may be attributed to CamSA's stability in the gut of antibiotic-treated mice and degradation by the microbiota in non-antibiotic treated animals.

BIOCHEMICAL PHARMACOLOGY (2021)

Article Microbiology

Omadacycline Compared to Vancomycin When Combined with Germinants To Disrupt the Life Cycle of Clostridioides difficile

Noah Budi et al.

Summary: Clostridioides difficile infections are commonly treated with antibiotics, but these do not impact the dormant spore form of the pathogen. This study found that combining germinants with omadacycline was more effective in eradicating spores compared to vancomycin, showing potential for preventing recurrent CDI and limiting spore shedding in healthcare settings.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

Article Microbiology

Modified Mouse Model of Clostridioides difficile Infection as a Platform for Probiotic Efficacy Studies

T. J. De Wolfe et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)

Letter Biotechnology & Applied Microbiology

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Evan Bolyen et al.

NATURE BIOTECHNOLOGY (2019)

Article Medicine, General & Internal

Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

Zachariah DeFilipp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Microbiology

Effect of the Synthetic Bile Salt Analog CamSA on the Hamster Model of Clostridium difficile Infection

Amber Howerton et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

Review Infectious Diseases

Microbiologic factors affecting Clostridium difficile recurrence

C. H. Chilton et al.

CLINICAL MICROBIOLOGY AND INFECTION (2018)

Article Public, Environmental & Occupational Health

Evaluation of Hospital Room Assignment and Acquisition of Clostridium difficile Infection

Megan K. Shaughnessy et al.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2011)

Article Public, Environmental & Occupational Health

Persistence of Skin Contamination and Environmental Shedding of Clostridium difficile during and after Treatment of C-difficile Infection

Ajay K. Sethi et al.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2010)

Article Microbiology

Effective and Reduced-Cost Modified Selective Medium for Isolation of Clostridium difficile

Michelle M. Nerandzic et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2009)

Article Gastroenterology & Hepatology

A Mouse Model of Clostridium difficile-Associated Disease

Xinhua Chen et al.

GASTROENTEROLOGY (2008)