Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections

Letter Medicine, General & Internal

Breakthrough infections with SARS-CoV-2 omicron despite mRNA vaccine booster dose

Constanze Kuhlmann et al.

LANCET (2022)

Article Infectious Diseases

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study

Anika Singanayagam et al.

Summary: Vaccination reduces the risk of delta variant infection and accelerates viral clearance. However, fully vaccinated individuals with breakthrough infections may still have similar peak viral loads as unvaccinated cases and can efficiently transmit the infection.

LANCET INFECTIOUS DISEASES (2022)

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Article Multidisciplinary Sciences

Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

Baisheng Li et al.

Summary: This article reports the first local transmission of the Delta variant in mainland China. Compared to A/B lineage infections during the first wave in China in early 2020, Delta infections had viral loads that were on average about 1000 times greater when they first tested positive, suggesting potentially faster viral replication and greater infectiousness during early infection. The transmission bottleneck size of the Delta variant was generally narrow, with 1-3 virions in most donor-recipient transmission pairs. However, transmission of minor intra-host variants resulted in at least 3 of the 34 substitutions identified in the outbreak, highlighting the contribution of intra-host variants to population-level viral diversity during rapid spread.

NATURE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

Infectious viral load in unvaccinated and vaccinated individuals infected with ancestral, Delta or Omicron SARS-CoV-2

Olha Puhach et al.

Summary: The infectious viral load of SARS-CoV-2 Omicron BA.1 is lower than that of Delta in breakthrough infections of vaccinated individuals. Vaccines may lower transmission risk and have a public health benefit.

NATURE MEDICINE (2022)

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Article Multidisciplinary Sciences

Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa

Juliet R. C. Pulliam et al.

Summary: This study provides two methods for monitoring reinfection trends in routine surveillance data. The results suggest immune evasion by the Omicron variant in previously infected individuals in South Africa, and there has been an increase in the risk of having a third infection since mid-November 2021.

SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Viral loads of Delta-variant SARS-CoV-2 breakthrough infections after vaccination and booster with BNT162b2

Matan Levine-Tiefenbrun et al.

Summary: The study found that the effectiveness of the BNT162b2 vaccine in reducing viral loads of breakthrough infections decreases over time. However, this reduction in viral load can be restored by receiving a third vaccine dose.

NATURE MEDICINE (2021)

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Article Infectious Diseases

Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs

Paolo Calistri et al.

Summary: A targeted surveillance in the Abruzzo region of Italy detected 313 persons affected by lineage B.1.1.7, with statistically significant differences in viral load and persistence compared to other lineages. In individuals infected with B.1.1.7 lineage, lower values of C-T associated with the detection of the N protein encoding gene and longer persistence of SARS-CoV-2 RNA in nasopharyngeal swabs were observed.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Letter Medicine, General & Internal

Viral Dynamics of SARS-CoV-2 Variants in Vaccinated and Unvaccinated Persons

Stephen M. Kissler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Infectious Diseases

SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis

Muge Cevik et al.

Summary: This study aimed to characterize the viral load dynamics, duration of viral shedding, and viable virus shedding of SARS-CoV-2 in various body fluids. The findings suggest that while SARS-CoV-2 RNA shedding can be prolonged in respiratory and stool samples, the duration of viable virus shedding is relatively short-lived.

LANCET MICROBE (2021)

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Article Oncology

Human papillomavirus 16 load in normal and abnormal cervical scrapes: An indicator of CINII/III and viral clearance

M van Duin et al.

INTERNATIONAL JOURNAL OF CANCER (2002)

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Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections

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