Journal
JOURNAL OF COORDINATION CHEMISTRY
Volume 69, Issue 10, Pages 1577-1586Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2016.1185518
Keywords
1; 3-Bis(benzimidazol-2-yl)-2-oxapropane; nickel(II) complex; crystal structure; DNA-binding property
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Funding
- National Natural Science Foundation of China [21367017]
- Natural Science Foundation of Gansu Province [1212RJZA037]
- Graduate student innovation projects of Lanzhou Jiaotong University
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[Ni(obb)(DMF)(2)(H2O)](Pic)(2)0.5DMF (1) and [Ni(Etobb)(2)](Pic)(2)2DMF (2) (obb=1,3-bis(benzimidazol-2-yl)-2-oxapropane, Etobb=1,3-bis(1-ethylbenzimidazol-2-yl)-2-oxapropane, Pic=picrate) have been synthesized and characterized by physicochemical and spectroscopic methods. The structures of both complexes have been determined by X-ray single-crystal diffraction. The coordination geometries of 1 and 2 can be described as distorted octahedra. The interaction of the nickel(II) complexes with calf thymus DNA was investigated by electronic absorption, fluorescence spectroscopy, and viscosity measurements. The experimental results suggest that 1 and 2 bind to DNA in an intercalation mode, and their binding affinity for DNA follows the order 1>2. DNA-binding behaviors can be attributed to the large coplanar aromatic rings in the V-shaped ligand and steric hindrance. [GRAPHICS] .
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