Journal
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 70, Issue 7, Pages 495-513Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1369/00221554221106812
Keywords
adrenergic receptor; autonomic nervous system; integrin; non-myelinating Schwann cell; norepinephrine; postganglionic neuron
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Funding
- Japan Society for Promotion of Science KAKENHI [17K08501, 21K06415]
- Grants-in-Aid for Scientific Research [21K06415, 17K08501] Funding Source: KAKEN
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This study investigated the spatial and molecular composition associations of renal Schwann cells supporting the nerve terminals in the kidney. It found that renal nerve terminals could contact their effectors via integrins and may have a structure suitable for releasing neurotransmitters.
Nerves in the renal parenchyma comprise sympathetic nerves that act on renal arteries and tubules to decrease blood flow and increase primary urine reabsorption, respectively. Synaptic vesicles release neurotransmitters that activate their effector tissues. However, the mechanisms by which neurotransmitters exert individual responses to renal effector cells remain unknown. Here, we investigated the spatial and molecular compositional associations of renal Schwann cells (SC) supporting the nerve terminals in male rats. The nerve terminals of vascular smooth muscle cells (SMCs) enclosed by renal SC processes were exposed through windows facing the effectors with presynaptic specializations. We found that the adrenergic receptors (ARs) alpha 2A, alpha 2C, and beta 2 were localized in the SMC and the basal side of the tubules, where the nerve terminals were attached, whereas the other subtypes of ARs were distributed in the glomerular and luminal side, where the norepinephrine released from nerve endings may have indirect access to ARs. In addition, integrins alpha 4 and beta 1 were coexpressed in the nerve terminals. Thus, renal nerve terminals could contact their effectors via integrins and may have a structure, covered by SC processes, suitable for intensive and directional release of neurotransmitters into the blood, rather than specialized structures in the postsynaptic region.
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