Catalyst-free one-pot synthesis of quinoline tethered α-amino ketones by multicomponent reactions

Herein we have reported a one-pot green methodology for the synthesis of quinoline tethered alpha-amino ketones. The reaction of arylglyoxal, 2-aminoquinoline, and 4-hydroxy-1-methylquinolin-2(1H)-one/barbituric acid in ethanol under reflux conditions provided the quinoline tethered alpha-amino ketones. The environmentally benign process, one-pot synthesis, readily available starting materials, short reaction time, easy purification process, good yields of the products, and the presence of several bioactive moieties such as quinolines and alpha-amino carbonyl in the product are the main advantages of this methodology. All the products were characterized by Fourier transform infrared (FTIR), nuclear magnetic resonance (H-1 NMR), C-13 NMR, and high-resolution mass spectrometry (HRMS). Single-crystal X-ray diffraction (XRD) of one compound was also reported.

Automated summary

In this study, a one-pot green method for the synthesis of quinoline tethered alpha-amino ketones was reported. The advantages of this method include its environmentally benign process, short reaction time, readily available starting materials, easy purification process, and high yields of the products.