Journal
JOURNAL OF CONTROLLED RELEASE
Volume 241, Issue -, Pages 174-185Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2016.09.016
Keywords
Extracellular vesicles; Exosomes; Microvesicles; Therapeutic delivery
Funding
- National Science Foundation [DGE-1321846]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT, and Future Planning (MSIP) of Korea [2016R1A2A1A05005465/2010-0027955]
- Brain Pool Program through the Korean Federation of Science and Technology Societies - MSIP
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Extracellular vesicles (EVs) hold great promise as potential therapeutic carriers. EVs are biologically active, intrinsically transporting cargo between cells. Moreover, they can be loaded with specific cargo for distribution and/or engineered to achieve enhanced uptake. Although studies have already demonstrated therapeutic delivery using EVs, various challenges must be overcome before EV technology is ready for the clinic. Since the properties of EVs are dependent upon their cell of origin and the conditions of their formation, establishing clear characterization practices is essential to ensuring reproducibility and safety. Identifying methods for mass production of EVs is crucial for achieving high EV yields necessary for clinical trials. This review introduces current theory behind EV formation and function, describes the latest methods for characterization and mass production, and discusses future opportunities for extracellular vesicles in therapeutic delivery. (C) 2016 Elsevier B.V. All rights reserved.
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