Implementing genomics in the neonatal period: An assessment of parental decision making and anxiety

As uptake of rapid genome sequencing (GS) in the neonatal period steadily increases, a clinical genetics service that is optimized to the needs of parents becomes increasingly important. We aimed to investigate factors that influence decision making about rapid GS by parents of infants admitted to neonatal intensive care units (NICU) and explore their experiences of decisional conflict and anxiety during this time. Parents of neonates suspected of having a genetic disorder and offered rapid GS in the NICU completed a questionnaire measuring experience with GS counseling, decisional conflict, and anxiety level. Our results demonstrate that despite a largely positive GS experience (70%; 21/30) among the survey respondents, 50.0% (14/28) experienced moderate to severe anxiety measured using the GAD-7 scale, and 34.6% (9/26) experienced decisional conflict measured using the SURE scale. We also showed that prematurity may be a modifier of anxiety in this group of parents and although not statistically significant, distance lived away from the hospital site could have practical significance. Open-ended responses to survey questions highlighted that feeling overwhelmed, the types of engagements parents had with healthcare providers, and the timing of information provision also influenced parental decision making in this setting. We suggest that the GAD-7 scale for generalized anxiety and SURE scale for decisional conflict could be incorporated by genetic counselors into routine care of parents of neonates who have been offered rapid GS to identify those who may need additional support (resources, information, or psychological). These tools may inform ways that communication between patients and providers can be improved and enhanced and clinical genetics services in the NICU can be optimized. We suggest that integrating genetic counselors into the NICU care team could increase access for this population and ensure delivery of optimized patient education and counseling.

Automated summary

This study investigated the factors that influence parental decision-making and their experiences during rapid genome sequencing (GS) in the neonatal intensive care unit (NICU). The results showed that while most parents had a positive experience with GS, a significant number experienced anxiety and decisional conflict. Prematurity and distance from the hospital site were found to be potential factors affecting parental anxiety. Open-ended responses highlighted the importance of feeling overwhelmed and the quality and timing of communication with healthcare providers. The findings suggest that the GAD-7 scale and SURE scale could be useful in identifying parents who may require additional support. Integrating genetic counselors into the NICU care team could also optimize patient education and counseling.