Journal
JOURNAL OF CONTROLLED RELEASE
Volume 225, Issue -, Pages 75-86Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2016.01.034
Keywords
Cryoprotectant; Lyophilization; Lyoprotectant; Nanoparticles; Polymer; Protein stability
Funding
- Fundacao para a Ciencia e a Tecnologia (FCT), Portugal [PTDC/SAL-FCT/104492/2008, SFRH/BD/78127/2011]
- European Regional Development Fund (ERDF) through the Programa Operacional Factores de Competitividade - COMPETE
- Portuguese funds through FCT [PEst-C/SAU/LA0002/2013]
- North Portugal Regional Operational Programme (ON.2 - O Novo Norte) under the National Strategic Reference Framework (NSRF)
- Fundação para a Ciência e a Tecnologia [SFRH/BD/78127/2011] Funding Source: FCT
Ask authors/readers for more resources
Lyophilization has been used to improve the long-term stability of polymeric nanoparticles for drug delivery applications, avoiding their instability in suspension. However, this dehydration process may induce stresses to nanoparticles, mitigated by the use of some excipients such as cryo-and lyoprotectants. Still, the lyophilization of polymeric nanoparticles is frequently based in empirical principles, without considering the physical-chemical properties of formulations and the engineering principles of lyophilization. Therefore, the optimization of formulations and the lyophilization cycle is crucial to obtain a good lyophilizate, and guarantee the preservation of nanoparticle stability. The proper characterization of the lyophilizate and nanoparticles has a great importance in achieving these purposes. This review updates the fundaments involved in the optimization procedures for lyophilization of polymeric nanoparticles, with the aim of obtaining the maximum stability of formulations. Different characterization methods to obtain and guarantee a good lyophilized product are also discussed. A special focus is given to encapsulated therapeutic proteins. Overall, this review is a contribution for the understanding of the parameters involved in the lyophilization of polymeric nanoparticles. This may definitely help future works to obtain lyophilized nanoparticles with good quality and with improved therapeutic benefits. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available