Journal
JOURNAL OF CONTROLLED RELEASE
Volume 237, Issue -, Pages 160-167Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2016.07.017
Keywords
Boron neutron capture therapy (BNCT); Closo-dodecaborate; Albumin modification; Maleimide; Boron delivery system
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [26293007]
- Terumo Foundation for Life Sciences and Arts
- Terumo Foundation for Life Science and Art
- Cooperative Research Program of Network Joint Research Center for Materials and Devices
- Grants-in-Aid for Scientific Research [26293007] Funding Source: KAKEN
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Maleimide-conjugating closo-dodecaborate sodium form 5c (MID) synthesized by the nucleophilic ring-opening reaction of closo-dodecaborate-1,4-dioxane complex 2 with tetrabutylammonium (TBA) azide was found to conjugate to free SH of cysteine and lysine residues in BSA under physiological conditions, forming highly boronated BSA that showed high and selective accumulation in tumor and significant tumor growth inhibition in colon 26 tumor-bearing mice subjected to thermal neutron irradiation. (C) 2016 Elsevier B.V. All rights reserved.
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