Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 219, Issue 9, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20220367
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Funding
- National Institutes of Health (NIH) [P01-AI138398-S1, 2U19AI111825, R37-AI64003, R01AI78788]
- CAPES (COMBATECovid) grant
- Rede Coronaomica Brazil-Ministerio da Ciencia, Tecnologia e Inovacoes/Financiadora de Estudos e Projetos grant
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [404096/2020]
- Bulgari Women & Science Fellowship in COVID-19 Research
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This paper describes the plasma and memory antibody response in a cohort of SARS-CoV-2 Gamma-infected individuals in Brazil. The results show that potent antibody neutralization is limited to Gamma and Beta variants, with lower neutralizing activity against other variants. Additionally, antibodies elicited by Gamma infection tend to recognize Class 3 epitopes more.
This paper describes the plasma and memory antibody response in a cohort of SARS-CoV-2 Gamma-infected individuals in Brazil. Potent antibody neutralization was shown to be limited to Gamma and Beta, and epitope recognition skewed to Class 3 epitopes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global problem in part because of the emergence of variants of concern that evade neutralization by antibodies elicited by prior infection or vaccination. Here we report on human neutralizing antibody and memory responses to the Gamma variant in a cohort of hospitalized individuals. Plasma from infected individuals potently neutralized viruses pseudotyped with Gamma SARS-CoV-2 spike protein, but neutralizing activity against Wuhan-Hu-1-1, Beta, Delta, or Omicron was significantly lower. Monoclonal antibodies from memory B cells also neutralized Gamma and Beta pseudoviruses more effectively than Wuhan-Hu-1. 69% and 34% of Gamma-neutralizing antibodies failed to neutralize Delta or Wuhan-Hu-1. Although Class 1 and 2 antibodies dominate the response to Wuhan-Hu-1 or Beta, 54% of antibodies elicited by Gamma infection recognized Class 3 epitopes. The results have implications for variant-specific vaccines and infections, suggesting that exposure to variants generally provides more limited protection to other variants.
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