Journal
JOURNAL OF CONTROLLED RELEASE
Volume 224, Issue -, Pages 22-32Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2015.12.039
Keywords
Carbon nanotubes; Brain drug delivery; Blood-brain barrier; Nanomedicine; SPECT/CT imaging; Multi-photon luminescence microscopy
Funding
- Biotechnology and Biological Sciences Research Council [BB/J008656/1]
- Worldwide Cancer Research [12-1054]
- ANTICARB [HEALTH-2007-201587]
- FP7-ITN Marie-Curie Network programme RADDEL [290023]
- Centre National de la Recherche Scientifique (CNRS)
- Atomic Energy Commission of Syria
- BBSRC [BB/J008656/1] Funding Source: UKRI
- EPSRC [EP/I014470/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J008656/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/I014470/1] Funding Source: researchfish
- Worldwide Cancer Research [12-1054] Funding Source: researchfish
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Earlier studies proved the success of using chemically functionalised multi-walled carbon nanotubes (f-MWNTs) as nanocarriers to the brain. Little insight into the kinetics of brain distribution of f-MWNTs in vivo has been reported. This study employed a wide range of qualitative and quantitative techniques with the aim of shedding the light on f-MWNT's brain distribution following intravenous injection. gamma-Scintigraphy quantified the uptake of studied radiolabelled f-MWNT in the whole brain parenchyma and capillaries while 3D-single photon emission computed tomography/computed tomography imaging and autoradiography illustrated spatial distribution within various brain regions. Raman and multiphoton luminescence together with transmission electron microscopy confirmed the presence of intact f-MWNT in mouse brain, in a label-free manner. The results evidenced the presence of f-MWNT in mice brain parenchyma, in addition to brain endothelium. Such information on the rate and extent of regional and cellular brain distribution is needed before further implementation into neurological therapeutics can be made. (C) 2016 The Authors. Published by Elsevier B.V.
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