PRAME expression is similar in scar and desmoplastic melanoma

Letter Cell Biology

PRAME immunoexpression in benign fibroblasts - a diagnostic pitfall

Craig Wakefield et al.

HISTOPATHOLOGY (2022)

Article Dermatology

Aberrant expression of HMB45 and negative PRAME expression in halo nevi

Kristen N. Ruby et al.

Summary: The study investigated the expression patterns of HMB45 and PRAME in nevi with the halo phenomenon (NHP) and conventional nevi, finding that aberrant HMB45 expression in NHP is not uncommon and may lead to diagnostic pitfalls. However, negative PRAME immunostaining can be a reassuring finding to help differentiate halo nevus from malignant melanoma.

JOURNAL OF CUTANEOUS PATHOLOGY (2021)

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Article Dermatology

Preferentially Expressed Antigen in Melanoma Immunostaining in a Series of Melanocytic Neoplasms

Paul B. Googe et al.

Summary: In melanocytic tumors, PRAME staining shows different degrees of positivity, with only a small proportion of nevi showing focal positivity, while the majority of melanomas (including in situ, invasive, and metastatic tumors) demonstrate diffuse positivity. Caution should be exercised in interpreting PRAME staining results in melanocytic tumors of uncertain classification, as some melanomas arising in association with nevus or atypical melanocytic tumors may exhibit focal or incomplete PRAME staining. Routine histopathological findings, clinical information, PRAME staining, and careful use of molecular studies are important steps in accurately classifying melanocytic neoplasia.

AMERICAN JOURNAL OF DERMATOPATHOLOGY (2021)

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Article Cell Biology

PRAME expression in melanocytic lesions of the conjunctiva

Daja Sekoranja et al.

Summary: PRAME expression was evaluated in various types of conjunctival melanocytic lesions, with most nevi showing no or only focal expression, while a high percentage of invasive melanomas and in-situ melanomas exhibited diffuse 4+ PRAME expression. This indicates that diffuse 4+ PRAME positivity is highly specific for malignant conjunctival melanocytic lesions and can aid in the diagnosis of suspected conjunctival melanoma.

HISTOPATHOLOGY (2021)

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Article Pathology