Self-assembled polysaccharide nanogel delivery system for overcoming tumor immune resistance

In therapeutic cancer vaccines, vaccine antigens must be efficiently delivered to the antigen-presenting cells (dendritic cells and macrophages) located in the lymphoid organs (lymph nodes and spleen) at the appropriate time to induce a potent antitumor immune response. Nanoparticle-based delivery systems in cancer immunotherapy are of great interest in recent year. We have developed a novel cancer vaccine that can use selfassembled polysaccharide nanogel of cholesteryl group-modified pullulan (CHP) as an antigen delivery system for clinical cancer immunotherapy for the first time. Additionally, we recently proposed a novel technology that uses CHP nanogels to regulate the function of tumor-associated macrophages, leading to an improvement in the tumor microenvironment. When combined with other immunotherapies, macrophage function modulation using CHP nanogels demonstrated a potent inhibitory effect against cancers resistant to immune checkpoint inhibition therapies. In this review, we discuss the applications of our unique drug nanodelivery system for CHP nanogels.

Automated summary

This article introduces a new cancer vaccine that uses self-assembled nanogels as an antigen delivery system for cancer immunotherapy. It also proposes a novel technology that utilizes nanogels to regulate tumor-associated macrophage function, leading to improved tumor microenvironment and potent inhibitory effect against immune checkpoint inhibition-resistant cancers.