Sustainable Synthesis of Azo-Linked 4-Arylidene-2-Aryloxazolones Using Fe3O4@SiPr@vanillin@TGA Nanocomposite

Bis(thioglycolic acid)-vanillin (2,2'-(((4-hydroxy-3-methoxyphenyl)methylene)bis(sulfanediyl))diacetic acid)-functionalized silica-coated Fe3O4 magnetic nanocomposite (Fe3O4 @SiPr @ vanillin @ TGA nanocomposite) were synthesized and characterized by field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), vibrating sample magnetometry (VSM), X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), X-ray spectroscopy (EDX), and fourier transform infrared spectroscopy (FT-IR). Fe3O4 @SiPr @vanillin @TGA supply an eco-friendly procedure for the synthesis of some novel 4-arylidene-2-aryloxazol-5-ones through one-pot reaction of various benzoyl chlorides, glycine, and synthetized azo-linked benzaldehydes. These compounds were obtained in high yields in short reaction times. The catalyst could be easily recovered and reused for six cycles with almost consistent activity. The structures of the synthesized 4-arylidene-2-aryloxazol-5-ones were confirmed by H-1 NMR, C-13 NMR and FTIR spectral data and elemental analyses. [GRAPHICS] .

Automated summary

A silica-coated Fe3O4 magnetic nanocomposite functionalized with bis(thioglycolic acid)-vanillin was synthesized and used as a catalyst for the synthesis of novel compounds. The catalyst exhibited high activity and could be easily recovered and reused.