Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1677, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2022.463297
Keywords
Cellulose; Emulsification; Chromatographic medium; Microspheres
Funding
- National Natural Science Founda- tion of China [21676170, 81803486]
- Sichuan Science and Technology Program [2019YJ0030]
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This paper describes the recent developments in the applications of cellulose-based absorbents as chromatographic medium, and explains the current situation of cellulose-based chromatographic medium from the aspects of cellulose dissolution, generation of spherical particles, and improvement of adsorption properties.
Cellulose is a kind of renewable linear polysaccharide with good safety, hydrophilicity, biocompatibility and biodegradability and has become a commonly used chromatographic medium for biological separation and purification. The purpose of this paper is to describe the recent developments in the applications of cellulose-based absorbents as chromatographic medium. This review also attempts to explain the current situation of cellulose-based chromatographic medium from the aspects of cellulose dissolution, common strategies for generating spherical particles of cellulose and its derivatives (such as titration, emulsification, microfluidic and other synthesis methods) and improvement of adsorption properties. Furthermore, non-spherical cellulose-based chromatographic medium are also described briefly. (c) 2022 Elsevier B.V. All rights reserved.
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