High information spectroscopic detection techniques for gas chromatography

Gas chromatography has always been a simple and widely used technique for the separation of volatile compounds and their quantitation. However, the common detectors used with this technique are mostly universal and do not provide any specific qualitative information. There have been some attempts to combine the separation power of GC with the qualitative capabilities of high-information spectroscopic techniques including infrared spectroscopy, nuclear magnetic resonance spectroscopy, molecular rotational resonance spectroscopy, and vacuum ultraviolet spectroscopy. Some of these hyphenations have proven to be quite successful while others were less so. The history of such attempts, up to the most recent studies in this area, are discussed. Most recently, the hyphenation of GC with molecular rotational resonance spectroscopy which provides promising results and is a newly developed technique is reviewed and compared to previous high-information spectroscopic detection approaches. The history, description and features of each method along with their applications and challenges are discussed. (c) 2022 Elsevier B.V. All rights reserved.

Automated summary

Gas chromatography is a widely used technique for the separation and quantitation of volatile compounds, but the common detectors used with this technique do not provide specific qualitative information. Attempts have been made to combine gas chromatography with high-information spectroscopic techniques to overcome this limitation. This article discusses the history and recent developments in this area, focusing on the hyphenation of gas chromatography with molecular rotational resonance spectroscopy, which has shown promising results.