Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 237, Issue 9, Pages 3435-3448Publisher
WILEY
DOI: 10.1002/jcp.30820
Keywords
hypoxia; integrated stress response; mitohormesis; mitokines; oxidative stress; stem cell
Categories
Ask authors/readers for more resources
This review provides an update on the broader concept of stem cell fate in stress conditions of damaged tissues, and highlights the importance of mitochondrial hormesis in the control of stem cell programming for successful clinical cell therapy.
The ability of stem cells for self-renewing, differentiation, and regeneration of injured tissues is believed to occur via the hormetic modulation of nuclear/mitochondrial signal transductions. The evidence now indicates that in damaged tissues, the mitochondria set off the alarm under oxidative stress conditions, hence they are the central regulators of stem cell fate decisions. This review aimed to provide an update to a broader concept of stem cell fate in stress conditions of damaged tissues, and insights for the mitochondrial hormesis (mitohormesis), including the integrated stress response (ISR), mitochondrial dynamics, mitochondria uncoupling, unfolded protein response, and mitokines, with implications for the control of stem cells programing in a successful clinical cell therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available