Journal
JOURNAL OF BIOPHOTONICS
Volume 15, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202200151
Keywords
label-free biosensors; microbubble resonators; whispering gallery modes
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Funding
- National Natural Science Foundation of China [62175035]
- Natural Science Foundation of Shanghai [21ZR1407400]
- Open-Foundation of Key Laboratory of Laser Device Technology, China North Industries Group Corporation Limited [KLLDT202108]
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Packaged microbubble resonators with thin wall are used for label-free and specific detection of cTnI based on WGM, showing great potential in detecting cardiac biomarkers of AMI.
The measurement of cardiac troponin-I (cTnI) is widely used for diagnosing acute myocardial infarction (AMI) diseases because of its myocardial specificity. Packaged microbubble resonators with thin wall are utilized for label-free and specific detection of cTnI based on whispering gallery mode (WGM). This packaged structure can provide a good protection for the biosensor, improve the anti-interference ability of the sensor and reduce the system noise. The theoretical detection limit of the biosensors for cTnI in phosphate buffer saline (PBS) is 0.4 ag mL(-1) (0.02 a(M)). Furthermore, we demonstrated that the biosensors can be used to detect cTnI molecules in simulated serum and the theoretical detection limit is also 0.4 ag mL(-1) (0.02 a(M)). These results are much far below the clinical cut-off value and show a huge application potential for the detection of cardiac biomarkers of AMI.
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