Journal
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Volume 41, Issue 12, Pages 5399-5417Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07391102.2022.2086922
Keywords
Mycobacterium tuberculosis; InhA; Chalcones; molecular modelling; toxicity
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Tuberculosis is a serious infectious disease caused by Mycobacterium tuberculosis. The study discovered potentially effective anti-TB therapies in the form of certain Chalcones compounds, which are believed to be due to their specific structures.
Tuberculosis (TB) is a serious infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). The World Health Organization (WHO) estimates that 1.8 million people die each year from TB, with 10 million new cases being registered each year. In this study, 50 Chalcones were developed, five of which were synthesized, and their inhibitory effects against Mtb were studied. The discovery of new powerful inhibitors with IC50 values in the sub-micro molar range resulted from the development of structure-activity relationships (SAR). The goal of the molecular modelling studies was to uncover the most important structural criteria underpinning the binding affinity and selectivity of this class of inhibitors as possible anti-TB drugs. Because of their great efficacy and selectivity, our developed nitro and benzyloxy substituted Chalcones compounds appear to be promising anti-TB therapies. Communicated by Ramaswamy H. Sarma
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